Detailed information of TA system TA286149

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1552569..1553148
• Replicon: chromosome
• Accession: NZ_LR130513
• Organism: Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EW029_RS07620
• Protein ID: WP_001025401.1
• Coordinates: 1552903..1553148 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1552569..1552934 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW029_RS07580	1549315..1549869	-	555	WP_000647288.1	DUF2815 family protein	-
EW029_RS07585	1549895..1551061	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
EW029_RS07590	1551058..1551420	-	363	WP_000985986.1	hypothetical protein	-
EW029_RS07595	1551435..1551758	-	324	WP_000175000.1	hypothetical protein	-
EW029_RS07600	1551837..1551998	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EW029_RS07605	1552011..1552274	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EW029_RS07610	1552299..1552514	-	216	WP_001097552.1	hypothetical protein	-
EW029_RS07615	1552569..1552934	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EW029_RS07620	1552903..1553148	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EW029_RS07625	1553215..1553595	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EW029_RS07630	1553582..1553779	-	198	WP_001148860.1	hypothetical protein	-
EW029_RS07635	1553849..1554061	+	213	WP_000362644.1	hypothetical protein	-
EW029_RS14570	1554102..1554251	-	150	WP_000771849.1	hypothetical protein	-
EW029_RS07640	1554266..1554709	-	444	WP_000435357.1	hypothetical protein	-
EW029_RS07645	1554750..1554968	-	219	WP_031783263.1	helix-turn-helix transcriptional regulator	-
EW029_RS07650	1555120..1555851	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EW029_RS07655	1555922..1556104	+	183	WP_000705240.1	hypothetical protein	-
EW029_RS07660	1556141..1556287	+	147	WP_001795334.1	hypothetical protein	-
EW029_RS07665	1556284..1556898	-	615	WP_000191464.1	hypothetical protein	-
EW029_RS07670	1557024..1557527	+	504	Protein_1448	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1511439..1579806	68367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T286149 WP_001025401.1 NZ_LR130513:c1553148-1552903 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT286149 NZ_LR130513:1552569-1552934 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin