Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 1516205..1516504 Replicon chromosome
Accession NZ_LR130513
Organism Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EW029_RS07370 Protein ID WP_011447039.1
Coordinates 1516328..1516504 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1516205..1516260 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW029_RS14565 1511439..1511654 - 216 WP_170267452.1 hypothetical protein -
EW029_RS07345 1511833..1512843 - 1011 WP_000777019.1 restriction endonuclease subunit S -
EW029_RS07350 1512830..1514734 - 1905 WP_001003363.1 N-6 DNA methylase -
EW029_RS07355 1515095..1515850 - 756 WP_000861038.1 CHAP domain-containing protein -
EW029_RS07360 1515862..1516116 - 255 WP_000611512.1 phage holin -
EW029_RS07365 1516168..1516275 + 108 WP_001791821.1 hypothetical protein -
- 1516197..1516336 + 140 NuclAT_0 - -
- 1516197..1516336 + 140 NuclAT_0 - -
- 1516197..1516336 + 140 NuclAT_0 - -
- 1516197..1516336 + 140 NuclAT_0 - -
- 1516205..1516260 + 56 - - Antitoxin
EW029_RS07370 1516328..1516504 - 177 WP_011447039.1 putative holin-like toxin Toxin
EW029_RS07375 1516657..1516956 - 300 WP_000466784.1 DUF2951 domain-containing protein -
EW029_RS07380 1517002..1517166 - 165 WP_000916020.1 XkdX family protein -
EW029_RS07385 1517159..1517548 - 390 WP_001166596.1 DUF2977 domain-containing protein -
EW029_RS07390 1517548..1519014 - 1467 WP_000067127.1 BppU family phage baseplate upper protein -
EW029_RS07395 1519014..1520924 - 1911 WP_000429558.1 minor structural protein -
EW029_RS07400 1520940..1521230 - 291 WP_000179858.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1511439..1579806 68367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T286147 WP_011447039.1 NZ_LR130513:c1516504-1516328 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT286147 NZ_LR130513:1516205-1516260 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References