Detailed information of TA system TA286146

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1516197..1516504
• Replicon: chromosome
• Accession: NZ_LR130513
• Organism: Staphylococcus aureus strain BPH2900 isolate BPH2900

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EW029_RS07370
• Protein ID: WP_011447039.1
• Coordinates: 1516328..1516504 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1516197..1516336 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW029_RS14565	1511439..1511654	-	216	WP_170267452.1	hypothetical protein	-
EW029_RS07345	1511833..1512843	-	1011	WP_000777019.1	restriction endonuclease subunit S	-
EW029_RS07350	1512830..1514734	-	1905	WP_001003363.1	N-6 DNA methylase	-
EW029_RS07355	1515095..1515850	-	756	WP_000861038.1	CHAP domain-containing protein	-
EW029_RS07360	1515862..1516116	-	255	WP_000611512.1	phage holin	-
EW029_RS07365	1516168..1516275	+	108	WP_001791821.1	hypothetical protein	-
-	1516197..1516336	+	140	NuclAT_0	-	Antitoxin
-	1516197..1516336	+	140	NuclAT_0	-	Antitoxin
-	1516197..1516336	+	140	NuclAT_0	-	Antitoxin
-	1516197..1516336	+	140	NuclAT_0	-	Antitoxin
EW029_RS07370	1516328..1516504	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EW029_RS07375	1516657..1516956	-	300	WP_000466784.1	DUF2951 domain-containing protein	-
EW029_RS07380	1517002..1517166	-	165	WP_000916020.1	XkdX family protein	-
EW029_RS07385	1517159..1517548	-	390	WP_001166596.1	DUF2977 domain-containing protein	-
EW029_RS07390	1517548..1519014	-	1467	WP_000067127.1	BppU family phage baseplate upper protein	-
EW029_RS07395	1519014..1520924	-	1911	WP_000429558.1	minor structural protein	-
EW029_RS07400	1520940..1521230	-	291	WP_000179858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1511439..1579806	68367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286146 WP_011447039.1 NZ_LR130513:c1516504-1516328 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT286146 NZ_LR130513:1516197-1516336 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin