Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2418562..2418746 Replicon chromosome
Accession NZ_LR130511
Organism Staphylococcus aureus strain BPH2819 isolate BPH2819

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag EW030_RS12550 Protein ID WP_000482652.1
Coordinates 2418639..2418746 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2418562..2418622 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW030_RS12525 2414017..2414184 - 168 Protein_2305 hypothetical protein -
EW030_RS12535 2414415..2416148 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
EW030_RS12540 2416173..2417936 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2418562..2418622 + 61 - - Antitoxin
EW030_RS12550 2418639..2418746 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
EW030_RS12555 2418880..2419266 - 387 WP_000779360.1 flippase GtxA -
EW030_RS12560 2419534..2420676 + 1143 WP_001176863.1 glycerate kinase -
EW030_RS12565 2420736..2421395 + 660 WP_000831298.1 membrane protein -
EW030_RS12570 2421577..2422788 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EW030_RS12575 2422911..2423384 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T286143 WP_000482652.1 NZ_LR130511:c2418746-2418639 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT286143 NZ_LR130511:2418562-2418622 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References