Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2393204..2393721 Replicon chromosome
Accession NZ_LR130511
Organism Staphylococcus aureus strain BPH2819 isolate BPH2819

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag EW030_RS12390 Protein ID WP_000113265.1
Coordinates 2393204..2393470 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EW030_RS12395 Protein ID WP_000584499.1
Coordinates 2393470..2393721 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW030_RS12360 2388632..2389168 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EW030_RS12365 2389402..2390226 - 825 WP_000572038.1 formate/nitrite transporter family protein -
EW030_RS12370 2390443..2390625 - 183 WP_000230292.1 hypothetical protein -
EW030_RS12375 2390709..2391176 - 468 WP_000153347.1 SRPBCC domain-containing protein -
EW030_RS12380 2391362..2392909 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EW030_RS12385 2393098..2393169 - 72 Protein_2280 hypothetical protein -
EW030_RS12390 2393204..2393470 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
EW030_RS12395 2393470..2393721 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW030_RS12400 2393886..2393987 - 102 Protein_2283 hypothetical protein -
EW030_RS12405 2393994..2394593 - 600 WP_000162810.1 DsbA family protein -
EW030_RS12410 2394612..2394974 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EW030_RS12415 2395229..2396479 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
EW030_RS12420 2396576..2397307 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EW030_RS12425 2397304..2398023 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T286142 WP_000113265.1 NZ_LR130511:c2393470-2393204 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286142 WP_000584499.1 NZ_LR130511:c2393721-2393470 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References