Detailed information of TA system TA286136

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1955832..1956131
• Replicon: chromosome
• Accession: NZ_LR130511
• Organism: Staphylococcus aureus strain BPH2819 isolate BPH2819

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EW030_RS09960
• Protein ID: WP_011447039.1
• Coordinates: 1955955..1956131 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1955832..1955889 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW030_RS09905	1950861..1951111	+	251	Protein_1825	sphingomyelin phosphodiesterase	-
EW030_RS09910	1951433..1951612	+	180	WP_000669789.1	hypothetical protein	-
EW030_RS09920	1951923..1952183	+	261	WP_001791826.1	hypothetical protein	-
EW030_RS09925	1952236..1952586	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
EW030_RS09930	1953097..1953435	-	339	Protein_1829	SH3 domain-containing protein	-
EW030_RS09940	1954040..1954531	-	492	WP_000920041.1	staphylokinase	-
EW030_RS09945	1954722..1955477	-	756	WP_000861038.1	CHAP domain-containing protein	-
EW030_RS09950	1955489..1955743	-	255	WP_000611512.1	phage holin	-
EW030_RS09955	1955795..1955902	+	108	WP_031790389.1	hypothetical protein	-
-	1955824..1955963	+	140	NuclAT_0	-	-
-	1955824..1955963	+	140	NuclAT_0	-	-
-	1955824..1955963	+	140	NuclAT_0	-	-
-	1955824..1955963	+	140	NuclAT_0	-	-
-	1955832..1955889	+	58	-	-	Antitoxin
EW030_RS09960	1955955..1956131	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EW030_RS09965	1956281..1956577	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
EW030_RS09970	1956635..1956922	-	288	WP_001040254.1	hypothetical protein	-
EW030_RS09975	1956969..1957121	-	153	WP_001153681.1	hypothetical protein	-
EW030_RS09980	1957111..1960896	-	3786	WP_061737661.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1952236..2002192	49956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T286136 WP_011447039.1 NZ_LR130511:c1956131-1955955 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 58 bp

>AT286136 NZ_LR130511:1955832-1955889 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin