Detailed information of TA system TA286134

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1802245..1802425
• Replicon: chromosome
• Accession: NZ_LR130511
• Organism: Staphylococcus aureus strain BPH2819 isolate BPH2819

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EW030_RS08940
• Protein ID: WP_001801861.1
• Coordinates: 1802245..1802340 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1802368..1802425 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EW030_RS08910	1797408..1798058	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
EW030_RS08915	1798139..1799134	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
EW030_RS08920	1799209..1799835	+	627	WP_000669024.1	hypothetical protein	-
EW030_RS08925	1799876..1800217	+	342	WP_000627540.1	DUF3969 family protein	-
EW030_RS08930	1800318..1800890	+	573	WP_000414216.1	hypothetical protein	-
EW030_RS08935	1801088..1802100	-	1013	Protein_1676	IS3 family transposase	-
EW030_RS08940	1802245..1802340	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1802368..1802425	-	58	-	-	Antitoxin
EW030_RS08945	1802463..1802564	+	102	WP_001792025.1	hypothetical protein	-
EW030_RS08950	1802542..1802703	-	162	Protein_1679	transposase	-
EW030_RS08955	1802694..1803188	-	495	Protein_1680	transposase	-
EW030_RS08960	1803640..1804869	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
EW030_RS08965	1804862..1806418	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
EW030_RS08970	1806582..1806716	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1796651..1861836	65185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T286134 WP_001801861.1 NZ_LR130511:1802245-1802340 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

Antitoxin

Nucleotide

• Length: 58 bp

>AT286134 NZ_LR130511:c1802425-1802368 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin