Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2441548..2442071 Replicon chromosome
Accession NZ_LR130509
Organism Staphylococcus aureus strain BPH2760 isolate BPH2760

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag EW032_RS12550 Protein ID WP_000074048.1
Coordinates 2441548..2441814 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag EW032_RS12555 Protein ID WP_000587616.1
Coordinates 2441814..2442071 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW032_RS12530 2436854..2438041 - 1188 WP_000026194.1 MFS transporter -
EW032_RS12535 2438437..2439213 - 777 WP_129621342.1 iron export ABC transporter permease subunit FetB -
EW032_RS12540 2439206..2439868 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
EW032_RS12545 2440116..2441192 - 1077 WP_001076671.1 M42 family metallopeptidase -
EW032_RS12550 2441548..2441814 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
EW032_RS12555 2441814..2442071 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW032_RS12565 2442430..2442885 + 456 WP_000732082.1 DUF1307 domain-containing protein -
EW032_RS12570 2443053..2444630 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
EW032_RS12575 2444826..2445575 + 750 WP_000072445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286132 WP_000074048.1 NZ_LR130509:c2441814-2441548 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286132 WP_000587616.1 NZ_LR130509:c2442071-2441814 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References