Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2384876..2385393 Replicon chromosome
Accession NZ_LR130509
Organism Staphylococcus aureus strain BPH2760 isolate BPH2760

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EW032_RS12230 Protein ID WP_000113262.1
Coordinates 2384876..2385142 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EW032_RS12235 Protein ID WP_000584499.1
Coordinates 2385142..2385393 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW032_RS12205 2380301..2380828 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
EW032_RS12210 2381072..2381896 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EW032_RS12215 2382113..2382295 - 183 WP_000230294.1 hypothetical protein -
EW032_RS12220 2382379..2382846 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EW032_RS12225 2383032..2384582 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EW032_RS12230 2384876..2385142 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EW032_RS12235 2385142..2385393 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EW032_RS12240 2385558..2385659 - 102 Protein_2250 hypothetical protein -
EW032_RS12245 2385666..2386265 - 600 WP_000162810.1 DsbA family protein -
EW032_RS12250 2386284..2386646 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EW032_RS12255 2386901..2388151 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EW032_RS12260 2388248..2388979 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
EW032_RS12265 2388976..2389695 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286130 WP_000113262.1 NZ_LR130509:c2385142-2384876 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286130 WP_000584499.1 NZ_LR130509:c2385393-2385142 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References