Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1605223..1605735 Replicon chromosome
Accession NZ_LR129841
Organism Streptococcus pneumoniae strain 947 isolate 947

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQB42_RS08360 Protein ID WP_000924721.1
Coordinates 1605223..1605477 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQB42_RS08365 Protein ID WP_000388572.1
Coordinates 1605481..1605735 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB42_RS08340 1600550..1600864 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQB42_RS08345 1600889..1601515 - 627 WP_000775037.1 guanylate kinase -
EQB42_RS08350 1601645..1603258 - 1614 WP_000404940.1 ribonuclease Y -
EQB42_RS08355 1603453..1604850 + 1398 WP_084588706.1 ISNCY family transposase -
EQB42_RS08360 1605223..1605477 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQB42_RS08365 1605481..1605735 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB42_RS08370 1605973..1607070 - 1098 WP_000156330.1 nucleotidyltransferase -
EQB42_RS08375 1607080..1607826 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQB42_RS08380 1607929..1608282 - 354 WP_001003001.1 ribosome silencing factor -
EQB42_RS08385 1608295..1608795 - 501 WP_000844713.1 cysteine hydrolase -
EQB42_RS08390 1608796..1609389 - 594 WP_000121651.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQB42_RS08395 1609389..1610018 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQB42_RS08400 1610070..1610381 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1603453..1604850 1397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T286109 WP_000924721.1 NZ_LR129841:c1605477-1605223 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT286109 WP_000388572.1 NZ_LR129841:c1605735-1605481 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References