286101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2747237..2747760 Replicon chromosome
Accession NZ_LR027878
Organism Staphylococcus aureus strain BPH2003 isolate BPH2003

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag E0E10_RS14640 Protein ID WP_000074048.1
Coordinates 2747237..2747503 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E0E10_RS14645 Protein ID WP_000587616.1
Coordinates 2747503..2747760 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E10_RS14620 2742544..2743731 - 1188 WP_000026194.1 MFS transporter -
E0E10_RS14625 2744127..2744903 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E0E10_RS14630 2744896..2745558 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
E0E10_RS14635 2745806..2746882 - 1077 WP_001076671.1 M42 family metallopeptidase -
E0E10_RS14640 2747237..2747503 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
E0E10_RS14645 2747503..2747760 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E10_RS14655 2748119..2748574 + 456 WP_000732080.1 DUF1307 domain-containing protein -
E0E10_RS14660 2748742..2750319 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E0E10_RS14665 2750514..2751263 + 750 WP_000072442.1 hypothetical protein -
E0E10_RS14670 2751487..2752680 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286101 WP_000074048.1 NZ_LR027878:c2747503-2747237 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286101 WP_000587616.1 NZ_LR027878:c2747760-2747503 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References