Detailed information of TA system TA286097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2423994..2424257
• Replicon: chromosome
• Accession: NZ_LR027878
• Organism: Staphylococcus aureus strain BPH2003 isolate BPH2003

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E0E10_RS12890
• Protein ID: WP_001802298.1
• Coordinates: 2424153..2424257 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2423994..2424158 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E10_RS12870	2420177..2420842	-	666	WP_001024094.1	SDR family oxidoreductase	-
E0E10_RS12875	2420994..2421314	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E0E10_RS12880	2421316..2422296	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E0E10_RS12885	2422562..2423653	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2423994..2424158	+	165	-	-	Antitoxin
E0E10_RS12890	2424153..2424257	-	105	WP_001802298.1	hypothetical protein	Toxin
E0E10_RS16355	2424418..2424901	-	484	Protein_2389	recombinase family protein	-
E0E10_RS12900	2424944..2426080	-	1137	WP_000115564.1	SAP domain-containing protein	-
E0E10_RS12905	2426369..2426461	+	93	WP_001790138.1	hypothetical protein	-
E0E10_RS12910	2427166..2428023	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E0E10_RS12915	2428091..2428873	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T286097 WP_001802298.1 NZ_LR027878:c2424257-2424153 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 165 bp

>AT286097 NZ_LR027878:2423994-2424158 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAGTAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin