Detailed information of TA system TA286089

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2119942..2120241
• Replicon: chromosome
• Accession: NZ_LR027878
• Organism: Staphylococcus aureus strain BPH2003 isolate BPH2003

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E0E10_RS11110
• Protein ID: WP_072482930.1
• Coordinates: 2120065..2120241 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2119942..2119997 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E10_RS11055	2115500..2115679	+	180	WP_000669789.1	hypothetical protein	-
E0E10_RS11065	2115990..2116250	+	261	WP_001791826.1	hypothetical protein	-
E0E10_RS11070	2116303..2116653	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E0E10_RS11075	2117163..2117498	-	336	Protein_2038	SH3 domain-containing protein	-
E0E10_RS11090	2118150..2118641	-	492	WP_000920041.1	staphylokinase	-
E0E10_RS11095	2118832..2119587	-	756	WP_000861038.1	CHAP domain-containing protein	-
E0E10_RS11100	2119599..2119853	-	255	WP_000611512.1	phage holin	-
E0E10_RS11105	2119905..2120012	+	108	Protein_2042	hypothetical protein	-
-	2119934..2120073	+	140	NuclAT_0	-	-
-	2119934..2120073	+	140	NuclAT_0	-	-
-	2119934..2120073	+	140	NuclAT_0	-	-
-	2119934..2120073	+	140	NuclAT_0	-	-
-	2119942..2119997	+	56	-	-	Antitoxin
E0E10_RS11110	2120065..2120241	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E0E10_RS11115	2120350..2121123	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E0E10_RS11120	2121496..2121870	-	375	WP_000340977.1	hypothetical protein	-
E0E10_RS11125	2121926..2122213	-	288	WP_001262621.1	hypothetical protein	-
E0E10_RS11130	2122259..2122411	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2116303..2173511	57208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T286089 WP_072482930.1 NZ_LR027878:c2120241-2120065 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286089 NZ_LR027878:2119942-2119997 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin