Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2572985..2573502 Replicon chromosome
Accession NZ_LR027877
Organism Staphylococcus aureus isolate BPH3244

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E0E14_RS13555 Protein ID WP_000113262.1
Coordinates 2572985..2573251 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E0E14_RS13560 Protein ID WP_000584499.1
Coordinates 2573251..2573502 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E14_RS13525 2568411..2568947 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E0E14_RS13530 2569180..2570004 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E0E14_RS13535 2570221..2570403 - 183 WP_000230294.1 hypothetical protein -
E0E14_RS13540 2570487..2570954 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E0E14_RS13545 2571140..2572690 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E0E14_RS13550 2572879..2572950 - 72 Protein_2505 hypothetical protein -
E0E14_RS13555 2572985..2573251 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E0E14_RS13560 2573251..2573502 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E14_RS13565 2573667..2573768 - 102 WP_001791744.1 hypothetical protein -
E0E14_RS13570 2573775..2574374 - 600 WP_000162813.1 DsbA family protein -
E0E14_RS13575 2574393..2574755 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E0E14_RS13580 2575010..2576260 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E0E14_RS13585 2576357..2577088 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E0E14_RS13590 2577085..2577804 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286082 WP_000113262.1 NZ_LR027877:c2573251-2572985 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286082 WP_000584499.1 NZ_LR027877:c2573502-2573251 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References