Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2569703..2570220 Replicon chromosome
Accession NZ_LR027876
Organism Staphylococcus aureus strain JKD6009 isolate JKD6009

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E0E12_RS13650 Protein ID WP_000113262.1
Coordinates 2569703..2569969 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E0E12_RS13655 Protein ID WP_000584499.1
Coordinates 2569969..2570220 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E12_RS13620 2565129..2565665 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E0E12_RS13625 2565898..2566722 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E0E12_RS13630 2566939..2567121 - 183 WP_000230294.1 hypothetical protein -
E0E12_RS13635 2567205..2567672 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E0E12_RS13640 2567858..2569408 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E0E12_RS13645 2569597..2569668 - 72 Protein_2521 hypothetical protein -
E0E12_RS13650 2569703..2569969 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E0E12_RS13655 2569969..2570220 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E12_RS13660 2570385..2570486 - 102 WP_001791744.1 hypothetical protein -
E0E12_RS13665 2570493..2571092 - 600 WP_000162813.1 DsbA family protein -
E0E12_RS13670 2571111..2571473 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E0E12_RS13675 2571728..2572978 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E0E12_RS13680 2573075..2573806 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E0E12_RS13685 2573803..2574522 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286065 WP_000113262.1 NZ_LR027876:c2569969-2569703 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286065 WP_000584499.1 NZ_LR027876:c2570220-2569969 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References