Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3655814..3656538 | Replicon | chromosome |
| Accession | NC_019776 | ||
| Organism | Cyanobacterium aponinum PCC 10605 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | K9Z9U6 |
| Locus tag | CYAN10605_RS15350 | Protein ID | WP_015220862.1 |
| Coordinates | 3655814..3656107 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CYAN10605_RS15355 | Protein ID | WP_015220863.1 |
| Coordinates | 3656233..3656538 (+) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CYAN10605_RS18925 | 3650908..3651081 | + | 174 | WP_015220857.1 | hypothetical protein | - |
| CYAN10605_RS15330 | 3651162..3651497 | - | 336 | WP_015220858.1 | photosystem II reaction center protein Psb28 | - |
| CYAN10605_RS15335 | 3651814..3652257 | + | 444 | WP_041922946.1 | hypothetical protein | - |
| CYAN10605_RS15340 | 3652282..3653148 | + | 867 | WP_015220860.1 | hypothetical protein | - |
| CYAN10605_RS15345 | 3653571..3655790 | - | 2220 | WP_015220861.1 | heavy metal translocating P-type ATPase | - |
| CYAN10605_RS15350 | 3655814..3656107 | + | 294 | WP_015220862.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CYAN10605_RS15355 | 3656233..3656538 | + | 306 | WP_015220863.1 | HigA family addiction module antidote protein | Antitoxin |
| CYAN10605_RS15360 | 3656550..3656861 | + | 312 | WP_015220864.1 | nucleotidyltransferase domain-containing protein | - |
| CYAN10605_RS15365 | 3656848..3657204 | + | 357 | WP_015220865.1 | DUF86 domain-containing protein | - |
| CYAN10605_RS15370 | 3657222..3657752 | - | 531 | WP_015220866.1 | hypothetical protein | - |
| CYAN10605_RS15375 | 3657841..3658125 | - | 285 | WP_015220867.1 | DUF5132 domain-containing protein | - |
| CYAN10605_RS15380 | 3658202..3658432 | - | 231 | WP_015220868.1 | ferrous iron transport protein A | - |
| CYAN10605_RS15385 | 3659058..3659279 | + | 222 | WP_015220869.1 | hypothetical protein | - |
| CYAN10605_RS15390 | 3659511..3660065 | - | 555 | WP_051018162.1 | fatty acid desaturase | - |
| CYAN10605_RS17965 | 3660120..3660359 | + | 240 | Protein_3069 | Red carotenoid-binding protein | - |
| CYAN10605_RS18930 | 3660390..3660503 | + | 114 | WP_190275002.1 | hypothetical protein | - |
| CYAN10605_RS15400 | 3660545..3660985 | - | 441 | WP_015220870.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11569.16 Da Isoelectric Point: 8.4838
>T28606 WP_015220862.1 NC_019776:3655814-3656107 [Cyanobacterium aponinum PCC 10605]
MIKSFKNKGTEDIFYGENSKLARKTCPQNLWQIARRKLDQLDSIISLAELKIPPGNQFEPLKGDRDGQYNIRINQQYRIC
FSWQNNHIWEVEIIDYH
MIKSFKNKGTEDIFYGENSKLARKTCPQNLWQIARRKLDQLDSIISLAELKIPPGNQFEPLKGDRDGQYNIRINQQYRIC
FSWQNNHIWEVEIIDYH
Download Length: 294 bp
>T28606 NC_019776:3655814-3656107 [Cyanobacterium aponinum PCC 10605]
ATGATTAAATCATTTAAAAATAAAGGCACAGAGGATATTTTTTATGGGGAAAATAGTAAATTAGCCCGAAAAACTTGTCC
TCAAAATCTTTGGCAAATAGCAAGAAGAAAATTAGATCAATTAGATTCTATAATTTCTTTAGCTGAATTAAAAATACCGC
CAGGTAATCAATTTGAACCCCTAAAGGGCGATCGAGATGGACAATATAATATTAGAATTAATCAACAATACCGTATCTGT
TTCTCTTGGCAAAATAACCATATTTGGGAAGTTGAAATAATCGATTATCACTAA
ATGATTAAATCATTTAAAAATAAAGGCACAGAGGATATTTTTTATGGGGAAAATAGTAAATTAGCCCGAAAAACTTGTCC
TCAAAATCTTTGGCAAATAGCAAGAAGAAAATTAGATCAATTAGATTCTATAATTTCTTTAGCTGAATTAAAAATACCGC
CAGGTAATCAATTTGAACCCCTAAAGGGCGATCGAGATGGACAATATAATATTAGAATTAATCAACAATACCGTATCTGT
TTCTCTTGGCAAAATAACCATATTTGGGAAGTTGAAATAATCGATTATCACTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11808.71 Da Isoelectric Point: 9.7210
>AT28606 WP_015220863.1 NC_019776:3656233-3656538 [Cyanobacterium aponinum PCC 10605]
MINIPTHRQPTHPGEMLLKEFLEPMGISQRELADKIRVPYQRVNEIVNCRRGISPSTALRLAKFFGTSADFWLNLQLRWD
LFHTQTKEKEVLAQIKEYIAS
MINIPTHRQPTHPGEMLLKEFLEPMGISQRELADKIRVPYQRVNEIVNCRRGISPSTALRLAKFFGTSADFWLNLQLRWD
LFHTQTKEKEVLAQIKEYIAS
Download Length: 306 bp
>AT28606 NC_019776:3656233-3656538 [Cyanobacterium aponinum PCC 10605]
ATGATCAACATTCCTACTCATAGACAACCAACCCATCCCGGAGAAATGCTACTGAAAGAGTTTTTAGAGCCTATGGGTAT
ATCACAAAGAGAATTAGCGGATAAAATCCGAGTGCCTTACCAGAGAGTAAATGAAATAGTAAATTGTCGTCGAGGCATTA
GCCCTAGTACAGCTCTACGCCTAGCCAAATTTTTCGGCACATCAGCAGACTTTTGGCTTAACCTTCAACTACGTTGGGAT
TTATTCCACACTCAAACAAAAGAAAAGGAAGTATTAGCCCAAATTAAAGAATATATTGCCAGTTAA
ATGATCAACATTCCTACTCATAGACAACCAACCCATCCCGGAGAAATGCTACTGAAAGAGTTTTTAGAGCCTATGGGTAT
ATCACAAAGAGAATTAGCGGATAAAATCCGAGTGCCTTACCAGAGAGTAAATGAAATAGTAAATTGTCGTCGAGGCATTA
GCCCTAGTACAGCTCTACGCCTAGCCAAATTTTTCGGCACATCAGCAGACTTTTGGCTTAACCTTCAACTACGTTGGGAT
TTATTCCACACTCAAACAAAAGAAAAGGAAGTATTAGCCCAAATTAAAGAATATATTGCCAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|