Detailed information of TA system TA286056

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2125152..2125451
• Replicon: chromosome
• Accession: NZ_LR027876
• Organism: Staphylococcus aureus strain JKD6009 isolate JKD6009

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E0E12_RS11185
• Protein ID: WP_072482930.1
• Coordinates: 2125275..2125451 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2125152..2125207 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E12_RS11150	2121675..2122241	+	567	WP_001807342.1	multidrug-binding transcriptional regulator QacR	-
E0E12_RS11155	2122374..2122559	-	186	WP_000797248.1	helix-turn-helix transcriptional regulator	-
E0E12_RS11160	2122564..2122902	-	339	WP_001049146.1	hypothetical protein	-
E0E12_RS11165	2123148..2123756	-	609	WP_000583528.1	recombinase family protein	-
E0E12_RS11170	2124039..2124302	+	264	WP_000495112.1	DUF4238 domain-containing protein	-
E0E12_RS11175	2124332..2125006	+	675	WP_001106019.1	IS6-like element IS257 family transposase	-
E0E12_RS11180	2125115..2125222	+	108	Protein_2058	hypothetical protein	-
-	2125144..2125283	+	140	NuclAT_0	-	-
-	2125144..2125283	+	140	NuclAT_0	-	-
-	2125144..2125283	+	140	NuclAT_0	-	-
-	2125144..2125283	+	140	NuclAT_0	-	-
-	2125152..2125207	+	56	-	-	Antitoxin
E0E12_RS11185	2125275..2125451	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E0E12_RS11190	2125560..2126333	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E0E12_RS11195	2126706..2127080	-	375	WP_000340977.1	hypothetical protein	-
E0E12_RS11200	2127136..2127423	-	288	WP_001262621.1	hypothetical protein	-
E0E12_RS11205	2127469..2127621	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / hlb / groEL	2122374..2177384	55010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T286056 WP_072482930.1 NZ_LR027876:c2125451-2125275 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286056 NZ_LR027876:2125152-2125207 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin