Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2638714..2639231 Replicon chromosome
Accession NZ_LR027874
Organism Staphylococcus aureus strain BPH2056 isolate BPH2056

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E0E13_RS13915 Protein ID WP_000113262.1
Coordinates 2638714..2638980 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E0E13_RS13920 Protein ID WP_000584499.1
Coordinates 2638980..2639231 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E13_RS13885 2634140..2634676 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E0E13_RS13890 2634909..2635733 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E0E13_RS13895 2635950..2636132 - 183 WP_000230294.1 hypothetical protein -
E0E13_RS13900 2636216..2636683 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E0E13_RS13905 2636869..2638419 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E0E13_RS13910 2638608..2638679 - 72 Protein_2583 hypothetical protein -
E0E13_RS13915 2638714..2638980 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E0E13_RS13920 2638980..2639231 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E13_RS13925 2639396..2639497 - 102 WP_001791744.1 hypothetical protein -
E0E13_RS13930 2639504..2640103 - 600 WP_000162813.1 DsbA family protein -
E0E13_RS13935 2640122..2640484 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E0E13_RS13940 2640739..2641989 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E0E13_RS13945 2642086..2642817 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E0E13_RS13950 2642814..2643533 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T286049 WP_000113262.1 NZ_LR027874:c2638980-2638714 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT286049 WP_000584499.1 NZ_LR027874:c2639231-2638980 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References