Detailed information of TA system TA286039

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2072387..2072686
• Replicon: chromosome
• Accession: NZ_LR027874
• Organism: Staphylococcus aureus strain BPH2056 isolate BPH2056

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E0E13_RS10745
• Protein ID: WP_072482930.1
• Coordinates: 2072510..2072686 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2072387..2072442 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E13_RS10690	2067945..2068124	+	180	WP_000669789.1	hypothetical protein	-
E0E13_RS10700	2068435..2068695	+	261	WP_001791826.1	hypothetical protein	-
E0E13_RS10705	2068748..2069098	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E0E13_RS10710	2069608..2069943	-	336	Protein_1973	SH3 domain-containing protein	-
E0E13_RS10725	2070595..2071086	-	492	WP_000920041.1	staphylokinase	-
E0E13_RS10730	2071277..2072032	-	756	WP_000861038.1	CHAP domain-containing protein	-
E0E13_RS10735	2072044..2072298	-	255	WP_000611512.1	phage holin	-
E0E13_RS10740	2072350..2072457	+	108	Protein_1977	hypothetical protein	-
-	2072379..2072518	+	140	NuclAT_0	-	-
-	2072379..2072518	+	140	NuclAT_0	-	-
-	2072379..2072518	+	140	NuclAT_0	-	-
-	2072379..2072518	+	140	NuclAT_0	-	-
-	2072387..2072442	+	56	-	-	Antitoxin
E0E13_RS10745	2072510..2072686	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E0E13_RS10750	2072795..2073568	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E0E13_RS10755	2073941..2074315	-	375	WP_000340977.1	hypothetical protein	-
E0E13_RS10760	2074371..2074658	-	288	WP_001262621.1	hypothetical protein	-
E0E13_RS10765	2074704..2074856	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2068748..2124619	55871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T286039 WP_072482930.1 NZ_LR027874:c2072686-2072510 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286039 NZ_LR027874:2072387-2072442 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin