Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2578265..2578788 Replicon chromosome
Accession NZ_LR027870
Organism Staphylococcus aureus strain BPH2019 isolate BPH2019

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag E0E15_RS13520 Protein ID WP_000074048.1
Coordinates 2578265..2578531 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E0E15_RS13525 Protein ID WP_000587616.1
Coordinates 2578531..2578788 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E15_RS13500 2573572..2574759 - 1188 WP_000026194.1 MFS transporter -
E0E15_RS13505 2575155..2575931 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E0E15_RS13510 2575924..2576586 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
E0E15_RS13515 2576834..2577910 - 1077 WP_001076671.1 M42 family metallopeptidase -
E0E15_RS13520 2578265..2578531 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
E0E15_RS13525 2578531..2578788 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E15_RS13530 2578894..2579088 - 195 WP_001790145.1 hypothetical protein -
E0E15_RS13535 2579147..2579602 + 456 WP_000732082.1 DUF1307 domain-containing protein -
E0E15_RS13540 2579770..2581347 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E0E15_RS13545 2581542..2582291 + 750 WP_000072442.1 hypothetical protein -
E0E15_RS13550 2582515..2583708 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286022 WP_000074048.1 NZ_LR027870:c2578531-2578265 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286022 WP_000587616.1 NZ_LR027870:c2578788-2578531 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References