Detailed information of TA system TA286013

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2081212..2081511
• Replicon: chromosome
• Accession: NZ_LR027870
• Organism: Staphylococcus aureus strain BPH2019 isolate BPH2019

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E0E15_RS10780
• Protein ID: WP_072482930.1
• Coordinates: 2081335..2081511 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2081212..2081267 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E15_RS10725	2076770..2076949	+	180	WP_000669789.1	hypothetical protein	-
E0E15_RS10735	2077260..2077520	+	261	WP_001791826.1	hypothetical protein	-
E0E15_RS10740	2077573..2077923	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E0E15_RS10745	2078433..2078768	-	336	Protein_1977	SH3 domain-containing protein	-
E0E15_RS10760	2079420..2079911	-	492	WP_000920041.1	staphylokinase	-
E0E15_RS10765	2080102..2080857	-	756	WP_000861038.1	CHAP domain-containing protein	-
E0E15_RS10770	2080869..2081123	-	255	WP_000611512.1	phage holin	-
E0E15_RS10775	2081175..2081282	+	108	Protein_1981	hypothetical protein	-
-	2081204..2081343	+	140	NuclAT_0	-	-
-	2081204..2081343	+	140	NuclAT_0	-	-
-	2081204..2081343	+	140	NuclAT_0	-	-
-	2081204..2081343	+	140	NuclAT_0	-	-
-	2081212..2081267	+	56	-	-	Antitoxin
E0E15_RS10780	2081335..2081511	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E0E15_RS10785	2081620..2082393	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E0E15_RS10790	2082766..2083140	-	375	WP_000340977.1	hypothetical protein	-
E0E15_RS10795	2083196..2083483	-	288	WP_001262621.1	hypothetical protein	-
E0E15_RS10800	2083529..2083681	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2075451..2131655	56204
	-	flank	IS/Tn	-	-	2075451..2076623	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T286013 WP_072482930.1 NZ_LR027870:c2081511-2081335 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT286013 NZ_LR027870:2081212-2081267 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin