286007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2633817..2634340 Replicon chromosome
Accession NZ_LR027869
Organism Staphylococcus aureus isolate BPH2869

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag E0E09_RS13995 Protein ID WP_000074048.1
Coordinates 2633817..2634083 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E0E09_RS14000 Protein ID WP_000587616.1
Coordinates 2634083..2634340 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E09_RS13975 2629124..2630311 - 1188 WP_000026194.1 MFS transporter -
E0E09_RS13980 2630707..2631483 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E0E09_RS13985 2631476..2632138 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
E0E09_RS13990 2632386..2633462 - 1077 WP_001076671.1 M42 family metallopeptidase -
E0E09_RS13995 2633817..2634083 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
E0E09_RS14000 2634083..2634340 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E0E09_RS14005 2634446..2634640 - 195 WP_001790145.1 hypothetical protein -
E0E09_RS14010 2634699..2635154 + 456 WP_000732082.1 DUF1307 domain-containing protein -
E0E09_RS14015 2635322..2636899 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E0E09_RS14020 2637094..2637843 + 750 WP_000072442.1 hypothetical protein -
E0E09_RS14025 2638067..2639260 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T286007 WP_000074048.1 NZ_LR027869:c2634083-2633817 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT286007 WP_000587616.1 NZ_LR027869:c2634340-2634083 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References