Detailed information of TA system TA286001

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2309238..2309517
• Replicon: chromosome
• Accession: NZ_LR027869
• Organism: Staphylococcus aureus isolate BPH2869

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E0E09_RS12235
• Protein ID: WP_001802298.1
• Coordinates: 2309413..2309517 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2309238..2309417 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E09_RS12215	2305437..2306102	-	666	WP_001024094.1	SDR family oxidoreductase	-
E0E09_RS12220	2306254..2306574	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E0E09_RS12225	2306576..2307556	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E0E09_RS12230	2307822..2308913	+	1092	WP_130826628.1	transcriptional regulator	-
-	2309238..2309417	+	180	-	-	Antitoxin
E0E09_RS12235	2309413..2309517	-	105	WP_001802298.1	hypothetical protein	Toxin
E0E09_RS15840	2309678..2310161	-	484	Protein_2256	recombinase family protein	-
E0E09_RS12245	2310204..2311340	-	1137	WP_000115564.1	SAP domain-containing protein	-
E0E09_RS12250	2311629..2311721	+	93	WP_001790138.1	hypothetical protein	-
E0E09_RS12255	2312426..2313283	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E0E09_RS12260	2313351..2314133	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T286001 WP_001802298.1 NZ_LR027869:c2309517-2309413 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT286001 NZ_LR027869:2309238-2309417 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin