Detailed information of TA system TA285996

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2133730..2134029
• Replicon: chromosome
• Accession: NZ_LR027869
• Organism: Staphylococcus aureus isolate BPH2869

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: E0E09_RS11225
• Protein ID: WP_072482930.1
• Coordinates: 2133853..2134029 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2133730..2133785 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E09_RS11170	2129288..2129467	+	180	WP_000669789.1	hypothetical protein	-
E0E09_RS11180	2129778..2130038	+	261	WP_001791826.1	hypothetical protein	-
E0E09_RS11185	2130091..2130441	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E0E09_RS11190	2130951..2131286	-	336	Protein_2059	SH3 domain-containing protein	-
E0E09_RS11205	2131938..2132429	-	492	WP_000920041.1	staphylokinase	-
E0E09_RS11210	2132620..2133375	-	756	WP_000861038.1	CHAP domain-containing protein	-
E0E09_RS11215	2133387..2133641	-	255	WP_000611512.1	phage holin	-
E0E09_RS11220	2133693..2133800	+	108	Protein_2063	hypothetical protein	-
-	2133722..2133861	+	140	NuclAT_0	-	-
-	2133722..2133861	+	140	NuclAT_0	-	-
-	2133722..2133861	+	140	NuclAT_0	-	-
-	2133722..2133861	+	140	NuclAT_0	-	-
-	2133730..2133785	+	56	-	-	Antitoxin
E0E09_RS11225	2133853..2134029	-	177	WP_072482930.1	putative holin-like toxin	Toxin
E0E09_RS11230	2134138..2134911	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E0E09_RS11235	2135284..2135658	-	375	WP_000340977.1	hypothetical protein	-
E0E09_RS11240	2135714..2136001	-	288	WP_001262621.1	hypothetical protein	-
E0E09_RS11245	2136047..2136199	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / sak / sea / hlb / groEL	2116017..2185973	69956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T285996 WP_072482930.1 NZ_LR027869:c2134029-2133853 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT285996 NZ_LR027869:2133730-2133785 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin