Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5518157..5518761 Replicon chromosome
Accession NZ_LR027557
Organism Pseudomonas synxantha strain 10586

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KR485_RS24570 Protein ID WP_057022036.1
Coordinates 5518447..5518761 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KR485_RS24565 Protein ID WP_003189536.1
Coordinates 5518157..5518444 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KR485_RS24530 5513433..5514191 + 759 WP_005786028.1 MBL fold metallo-hydrolase -
KR485_RS24535 5514219..5514932 + 714 WP_005786030.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KR485_RS24545 5515201..5515494 - 294 WP_057022032.1 type II toxin-antitoxin system RelE/ParE family toxin -
KR485_RS24550 5515484..5515723 - 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KR485_RS24555 5516367..5516618 + 252 WP_103733513.1 DUF3077 domain-containing protein -
KR485_RS24560 5516692..5517918 - 1227 WP_032877262.1 MFS transporter -
KR485_RS24565 5518157..5518444 - 288 WP_003189536.1 NadS family protein Antitoxin
KR485_RS24570 5518447..5518761 - 315 WP_057022036.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KR485_RS24575 5518867..5519808 - 942 WP_216090883.1 LysR family transcriptional regulator -
KR485_RS24580 5519966..5521282 + 1317 WP_216090884.1 MFS transporter -
KR485_RS24585 5521294..5522526 + 1233 WP_216090885.1 Zn-dependent hydrolase -
KR485_RS24590 5522661..5523698 + 1038 WP_216090886.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - mucA / mucD 5505006..5518761 13755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11656.44 Da        Isoelectric Point: 9.8054

>T285991 WP_057022036.1 NZ_LR027557:c5518761-5518447 [Pseudomonas synxantha]
MIFIETSVFTRRVKELIDEDAYTALQNVLVVNPSAGDVIEGTGGVRKIRVAAKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTADERKSLKAAIEHWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10828.41 Da        Isoelectric Point: 7.3219

>AT285991 WP_003189536.1 NZ_LR027557:c5518444-5518157 [Pseudomonas synxantha]
MSRFFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References