Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3553566..3554236 Replicon chromosome
Accession NZ_LR027516
Organism Mycobacterium tuberculosis strain DKC2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag DKC2_RS17430 Protein ID WP_003899954.1
Coordinates 3553566..3553910 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag DKC2_RS17435 Protein ID WP_003899955.1
Coordinates 3553907..3554236 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC2_RS17395 3548639..3549499 + 861 WP_003416628.1 alpha/beta hydrolase -
DKC2_RS17400 3549474..3549989 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
DKC2_RS17410 3550229..3550522 + 294 WP_003416635.1 hypothetical protein -
DKC2_RS17415 3550810..3552099 + 1290 WP_003416640.1 ATP-binding protein -
DKC2_RS17420 3552446..3552880 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
DKC2_RS17425 3552883..3553335 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DKC2_RS17430 3553566..3553910 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DKC2_RS17435 3553907..3554236 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
DKC2_RS17440 3554774..3555121 + 348 WP_003899956.1 DUF2384 domain-containing protein -
DKC2_RS17445 3555118..3555738 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
DKC2_RS17450 3555898..3557163 - 1266 WP_003912135.1 hypothetical protein -
DKC2_RS17455 3557331..3557540 + 210 WP_003416778.1 hypothetical protein -
DKC2_RS17465 3557787..3558821 - 1035 WP_003416786.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T285977 WP_003899954.1 NZ_LR027516:3553566-3553910 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT285977 WP_003899955.1 NZ_LR027516:3553907-3554236 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References