Detailed information of TA system TA285898

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2358352..2358723
• Replicon: chromosome
• Accession: NZ_LR025101
• Organism: Escherichia coli isolate EC-1639

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: EC1639_RS11395
• Protein ID: WP_001317028.1
• Coordinates: 2358529..2358723 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2358352..2358530 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EC1639_RS11370	2354307..2355680	+	1374	WP_000123754.1	ATP-dependent RNA helicase DbpA	-
EC1639_RS11375	2355809..2356744	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
EC1639_RS11380	2356796..2358031	-	1236	WP_000040858.1	site-specific integrase	-
EC1639_RS11385	2358033..2358248	-	216	WP_000079604.1	excisionase XisR	-
EC1639_RS11390	2358327..2358536	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	2358352..2358530	+	179	NuclAT_0	-	Antitoxin
-	2358352..2358530	+	179	NuclAT_0	-	Antitoxin
-	2358352..2358530	+	179	NuclAT_0	-	Antitoxin
-	2358352..2358530	+	179	NuclAT_0	-	Antitoxin
EC1639_RS11395	2358529..2358723	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
EC1639_RS11400	2358780..2359589	-	810	WP_000166319.1	recombination protein RecT	-
EC1639_RS11405	2359582..2362182	-	2601	WP_001586992.1	exodeoxyribonuclease VIII	-
EC1639_RS11410	2362284..2362559	-	276	WP_000632297.1	protein RacC	-
EC1639_RS11415	2362634..2362804	-	171	WP_001352098.1	conserved protein, Rac prophage	-
EC1639_RS11420	2362804..2363025	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2356796..2404348	47552

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T285898 WP_001317028.1 NZ_LR025101:c2358723-2358529 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

Antitoxin

Nucleotide

• Length: 179 bp

>AT285898 NZ_LR025101:2358352-2358530 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin