Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 5000079..5000665 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag EC12536_RS24875 Protein ID WP_002920800.1
Coordinates 5000079..5000447 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag EC12536_RS24880 Protein ID WP_004174006.1
Coordinates 5000444..5000665 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS24855 4995582..4996652 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
EC12536_RS24860 4996654..4997499 - 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
EC12536_RS24865 4997496..4998383 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
EC12536_RS24870 4998490..4999806 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
EC12536_RS24875 5000079..5000447 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
EC12536_RS24880 5000444..5000665 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EC12536_RS24885 5000829..5001542 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
EC12536_RS24890 5001544..5002311 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
EC12536_RS24895 5002308..5003585 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
EC12536_RS24900 5003582..5004508 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4994845..5003585 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T285882 WP_002920800.1 NZ_LR025099:c5000447-5000079 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT285882 WP_004174006.1 NZ_LR025099:c5000665-5000444 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References