Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4224853..4225652 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag EC7215_RS20435 Protein ID WP_000347267.1
Coordinates 4225188..4225652 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EC7215_RS20430 Protein ID WP_001307405.1
Coordinates 4224853..4225188 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS20415 4220638..4221408 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
EC7215_RS20420 4221424..4222758 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
EC7215_RS20425 4223133..4224704 + 1572 WP_001273741.1 galactarate dehydratase -
EC7215_RS20430 4224853..4225188 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EC7215_RS20435 4225188..4225652 + 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EC7215_RS20440 4225707..4226516 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EC7215_RS20445 4226765..4228045 + 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
EC7215_RS20450 4228068..4228541 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EC7215_RS20455 4228552..4229331 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EC7215_RS20460 4229321..4230199 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EC7215_RS20465 4230217..4230651 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4214197..4225652 11455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T285864 WP_000347267.1 NZ_LR025096:4225188-4225652 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT285864 WP_001307405.1 NZ_LR025096:4224853-4225188 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References