Detailed information of TA system TA028586

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2720834..2721108
• Replicon: chromosome
• Accession: NC_019770
• Organism: Enterococcus faecalis str. Symbioflor 1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: EFS1_RS14575
• Protein ID: WP_073340360.1
• Coordinates: 2720834..2720974 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2720907..2721108 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFS1_RS13605	2716041..2717033	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
EFS1_RS13610	2717297..2717935	-	639	WP_015212268.1	lytic polysaccharide monooxygenase	-
EFS1_RS13620	2718621..2720237	+	1617	WP_015212269.1	phosphatase PAP2/LCP family protein	-
EFS1_RS14570	2720566..2720715	+	150	WP_002411240.1	putative holin-like toxin	-
EFS1_RS14575	2720834..2720974	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2720907..2721108	-	202	-	-	Antitoxin
EFS1_RS13625	2721205..2721348	+	144	WP_002381035.1	putative holin-like toxin	-
EFS1_RS13630	2721543..2725370	-	3828	WP_002389430.1	WxL domain-containing protein	-
EFS1_RS13635	2725357..2725719	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T28586 WP_073340360.1 NC_019770:2720834-2720974 [Enterococcus faecalis str. Symbioflor 1]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T28586 NC_019770:2720834-2720974 [Enterococcus faecalis str. Symbioflor 1]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT28586 NC_019770:c2721108-2720907 [Enterococcus faecalis str. Symbioflor 1]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin