285848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 206447..207049 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag EC7215_RS01000 Protein ID WP_000897305.1
Coordinates 206447..206758 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EC7215_RS01005 Protein ID WP_000356397.1
Coordinates 206759..207049 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS00970 201477..202262 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
EC7215_RS00975 202361..202960 + 600 WP_001295269.1 glucose-1-phosphatase -
EC7215_RS00980 202954..203826 + 873 WP_072643613.1 virulence factor BrkB family protein -
EC7215_RS00985 203823..204260 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
EC7215_RS00990 204305..205246 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
EC7215_RS00995 205310..206218 - 909 WP_001162704.1 alpha/beta hydrolase -
EC7215_RS01000 206447..206758 + 312 WP_000897305.1 hypothetical protein Toxin
EC7215_RS01005 206759..207049 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EC7215_RS01010 207654..207872 + 219 WP_001297075.1 ribbon-helix-helix domain-containing protein -
EC7215_RS01015 208091..208333 + 243 WP_001086388.1 hypothetical protein -
EC7215_RS01020 208663..209592 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
EC7215_RS01025 209589..210224 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
EC7215_RS01030 210221..211123 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T285848 WP_000897305.1 NZ_LR025096:206447-206758 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT285848 WP_000356397.1 NZ_LR025096:206759-207049 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References