Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4395673..4396313 Replicon chromosome
Accession NZ_LR025092
Organism Klebsiella pneumoniae isolate KP9201

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag KP920_RS22170 Protein ID WP_016529833.1
Coordinates 4395966..4396313 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KP920_RS22165 Protein ID WP_040181955.1
Coordinates 4395673..4395966 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP920_RS22145 4391872..4392630 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
KP920_RS22150 4392680..4393510 - 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
KP920_RS22155 4393561..4393890 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KP920_RS22160 4394095..4395603 + 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
KP920_RS22165 4395673..4395966 - 294 WP_040181955.1 helix-turn-helix transcriptional regulator Antitoxin
KP920_RS22170 4395966..4396313 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP920_RS22175 4396489..4398936 - 2448 WP_002920561.1 glycogen phosphorylase -
KP920_RS22180 4398954..4400387 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T285841 WP_016529833.1 NZ_LR025092:c4396313-4395966 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT285841 WP_040181955.1 NZ_LR025092:c4395966-4395673 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure

References