Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 143253..143788 Replicon plasmid II
Accession NZ_LN999988
Organism Enterococcus faecium isolate EFE11651

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag EFE1165_RS15050 Protein ID WP_002305108.1
Coordinates 143516..143788 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag EFE1165_RS15045 Protein ID WP_002303154.1
Coordinates 143253..143516 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFE1165_RS15020 138723..140330 + 1608 WP_002311053.1 Nramp family divalent metal transporter -
EFE1165_RS15025 140339..140776 + 438 WP_002307485.1 universal stress protein -
EFE1165_RS15035 142162..142725 + 564 Protein_154 IS6 family transposase -
EFE1165_RS15040 142731..143147 + 417 WP_002303153.1 hypothetical protein -
EFE1165_RS15045 143253..143516 + 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EFE1165_RS15050 143516..143788 + 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
EFE1165_RS15055 143865..144194 + 330 WP_002292678.1 AbrB family transcriptional regulator -
EFE1165_RS15060 144184..144471 + 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
EFE1165_RS15065 144757..145614 + 858 WP_002292680.1 AAA family ATPase -
EFE1165_RS15070 145615..146163 + 549 WP_002292681.1 hypothetical protein -
EFE1165_RS15075 146460..147407 - 948 WP_002303155.1 DNA-binding transcriptional regulator -
EFE1165_RS15080 147595..148782 + 1188 WP_002303156.1 NADP-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..192533 192533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T285814 WP_002305108.1 NZ_LN999988:143516-143788 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT285814 WP_002303154.1 NZ_LN999988:143253-143516 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References