Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3626..4211 Replicon plasmid II
Accession NZ_LN997847
Organism Acinetobacter baumannii isolate R2091

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ABR2091_RS18425 Protein ID WP_058207830.1
Coordinates 3891..4211 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ABR2091_RS18420 Protein ID WP_004896911.1
Coordinates 3626..3898 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABR2091_RS18395 1..933 + 933 WP_002124966.1 replication initiation protein RepM -
ABR2091_RS18400 975..1553 + 579 WP_197556496.1 plasmid replication DNA-binding protein -
ABR2091_RS19135 1573..1716 + 144 WP_171253639.1 hypothetical protein -
ABR2091_RS18405 1912..2253 + 342 WP_058207825.1 hypothetical protein -
ABR2091_RS18410 2377..3081 - 705 WP_058207826.1 hypothetical protein -
ABR2091_RS18420 3626..3898 - 273 WP_004896911.1 helix-turn-helix domain-containing protein Antitoxin
ABR2091_RS18425 3891..4211 - 321 WP_058207830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABR2091_RS18430 4463..4684 + 222 WP_057695020.1 hypothetical protein -
ABR2091_RS18435 5016..5207 - 192 WP_057695016.1 YqaE/Pmp3 family membrane protein -
ABR2091_RS18440 5237..5518 - 282 WP_144431835.1 mobilization protein -
ABR2091_RS18445 5728..7161 + 1434 WP_058207828.1 MobA/MobL family protein -
ABR2091_RS18450 7263..7508 + 246 WP_058207829.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..7742 7742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12250.06 Da        Isoelectric Point: 7.9835

>T285802 WP_058207830.1 NZ_LN997847:c4211-3891 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVNDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSLKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10126.59 Da        Isoelectric Point: 7.2045

>AT285802 WP_004896911.1 NZ_LN997847:c3898-3626 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References