Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 459472..460083 Replicon chromosome
Accession NZ_LN890656
Organism Candidatus Promineofilum breve strain Cfx-K

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag CFX0092_RS19145 Protein ID WP_095045268.1
Coordinates 459472..459753 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFX0092_RS19150 Protein ID WP_197699976.1
Coordinates 459772..460083 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFX0092_RS19125 454829..455749 - 921 WP_095045265.1 GNAT family N-acetyltransferase -
CFX0092_RS19130 455749..456252 - 504 WP_197699975.1 MaoC family dehydratase -
CFX0092_RS19135 456328..457062 - 735 WP_157913340.1 class I SAM-dependent methyltransferase -
CFX0092_RS19140 457218..459422 + 2205 WP_095045267.1 acyl-CoA mutase large subunit family protein -
CFX0092_RS19145 459472..459753 + 282 WP_095045268.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFX0092_RS19150 459772..460083 + 312 WP_197699976.1 HigA family addiction module antidote protein Antitoxin
CFX0092_RS19155 460161..462338 + 2178 WP_095045269.1 methylmalonyl-CoA mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(9-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11115.66 Da        Isoelectric Point: 9.6833

>T285783 WP_095045268.1 NZ_LN890656:459472-459753 [Candidatus Promineofilum breve]
MIRSFASKETEKLFRRQFSRKLPEDIQRKARIKLEILDAAGRLNDLRIPPSNRLEKLSGDREGQYSIRINSQWRICFKWE
DDAAHDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12225.36 Da        Isoelectric Point: 9.9441

>AT285783 WP_197699976.1 NZ_LN890656:459772-460083 [Candidatus Promineofilum breve]
MMDKNELLPPIHPGEILLEEFLQPLKISQYRLAKDMGVPVRRINEIVLGKRRITADTALRLARYFGLSERFWMNLQTRYD
LEVEKDRLRDRLEREVKVFAAAI

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References