Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2427297..2427898 Replicon chromosome
Accession NZ_LN890655
Organism Candidatus Promineofilum breve strain Cfx-K

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFX0092_RS10515 Protein ID WP_095043486.1
Coordinates 2427297..2427581 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CFX0092_RS10520 Protein ID WP_095043487.1
Coordinates 2427593..2427898 (+) Length 102 a.a.

Genomic Context

CFX0092_RS10490CFX0092_RS10510CFX0092_RS10515CFX0092_RS10520CFX0092_RS10495CFX0092_RS10500CFX0092_RS10505CFX0092_RS10525CFX0092_RS10530CFX0092_RS10535CFX0092_RS10540CFX0092_RS10545
Location: 2422316..2422696 (381 bp)
Type: Others
Protein ID: WP_095043481.1
Location: 2426317..2427225 (909 bp)
Type: Others
Protein ID: WP_095043485.1
Location: 2427297..2427581 (285 bp)
Type: Toxin
Protein ID: WP_095043486.1
Location: 2427593..2427898 (306 bp)
Type: Antitoxin
Protein ID: WP_095043487.1
Location: 2422736..2423764 (1029 bp)
Type: Others
Protein ID: WP_095043482.1
Location: 2423861..2424892 (1032 bp)
Type: Others
Protein ID: WP_095043483.1
Location: 2424992..2426131 (1140 bp)
Type: Others
Protein ID: WP_095043484.1
Location: 2427949..2428302 (354 bp)
Type: Others
Protein ID: WP_095043488.1
Location: 2428307..2428534 (228 bp)
Type: Others
Protein ID: WP_095043489.1
Location: 2428597..2430168 (1572 bp)
Type: Others
Protein ID: WP_162292475.1
Location: 2430165..2431115 (951 bp)
Type: Others
Protein ID: WP_095043491.1
Location: 2431118..2431315 (198 bp)
Type: Others
Protein ID: WP_095043492.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CFX0092_RS104902422316..2422696+381WP_095043481.1hypothetical protein-
CFX0092_RS104952422736..2423764-1029WP_095043482.1C40 family peptidase-
CFX0092_RS105002423861..2424892-1032WP_095043483.1dipeptide epimerase-
CFX0092_RS105052424992..2426131-1140WP_095043484.1M20 family metallopeptidase-
CFX0092_RS105102426317..2427225+909WP_095043485.1hypothetical protein-
CFX0092_RS105152427297..2427581+285WP_095043486.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CFX0092_RS105202427593..2427898+306WP_095043487.1HigA family addiction module antidote proteinAntitoxin
CFX0092_RS105252427949..2428302-354WP_095043488.1DUF5615 family PIN-like protein-
CFX0092_RS105302428307..2428534-228WP_095043489.1DUF433 domain-containing protein-
CFX0092_RS105352428597..2430168-1572WP_162292475.1YhfC family intramembrane metalloprotease-
CFX0092_RS105402430165..2431115-951WP_095043491.1ABC transporter ATP-binding protein-
CFX0092_RS105452431118..2431315-198WP_095043492.1PLD nuclease N-terminal domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11086.64 Da        Isoelectric Point: 9.6242

>T285781 WP_095043486.1 NZ_LN890655:2427297-2427581 [Candidatus Promineofilum breve]
VIVSFASRETELIFHGRVSRKLPHDIQRTARRKLLYLHDAEDLRDLLAPPGNKLEKLKGDREGQYSIRINDQWRICFRWT
SGRALDVEIVDYHS

Download         Length: 285 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11434.17 Da        Isoelectric Point: 6.4707

>AT285781 WP_095043487.1 NZ_LN890655:2427593-2427898 [Candidatus Promineofilum breve]
MTEETLPPIHPGEVLLEDFMKPLGLSQYRVAQDIGVPALRISQIVHGKRAVTADSAMRLARYFGTSPDVWLRLQARYDLE
VAEREYGERINREVKVLANAV

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References