Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2427297..2427898 Replicon chromosome
Accession NZ_LN890655
Organism Candidatus Promineofilum breve strain Cfx-K

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CFX0092_RS10515 Protein ID WP_095043486.1
Coordinates 2427297..2427581 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CFX0092_RS10520 Protein ID WP_095043487.1
Coordinates 2427593..2427898 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFX0092_RS10490 2422316..2422696 + 381 WP_095043481.1 hypothetical protein -
CFX0092_RS10495 2422736..2423764 - 1029 WP_095043482.1 C40 family peptidase -
CFX0092_RS10500 2423861..2424892 - 1032 WP_095043483.1 dipeptide epimerase -
CFX0092_RS10505 2424992..2426131 - 1140 WP_095043484.1 M20 family metallopeptidase -
CFX0092_RS10510 2426317..2427225 + 909 WP_095043485.1 hypothetical protein -
CFX0092_RS10515 2427297..2427581 + 285 WP_095043486.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFX0092_RS10520 2427593..2427898 + 306 WP_095043487.1 HigA family addiction module antidote protein Antitoxin
CFX0092_RS10525 2427949..2428302 - 354 WP_095043488.1 DUF5615 family PIN-like protein -
CFX0092_RS10530 2428307..2428534 - 228 WP_095043489.1 DUF433 domain-containing protein -
CFX0092_RS10535 2428597..2430168 - 1572 WP_162292475.1 YhfC family intramembrane metalloprotease -
CFX0092_RS10540 2430165..2431115 - 951 WP_095043491.1 ABC transporter ATP-binding protein -
CFX0092_RS10545 2431118..2431315 - 198 WP_095043492.1 PLD nuclease N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11086.64 Da        Isoelectric Point: 9.6242

>T285781 WP_095043486.1 NZ_LN890655:2427297-2427581 [Candidatus Promineofilum breve]
VIVSFASRETELIFHGRVSRKLPHDIQRTARRKLLYLHDAEDLRDLLAPPGNKLEKLKGDREGQYSIRINDQWRICFRWT
SGRALDVEIVDYHS

Download         Length: 285 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11434.17 Da        Isoelectric Point: 6.4707

>AT285781 WP_095043487.1 NZ_LN890655:2427593-2427898 [Candidatus Promineofilum breve]
MTEETLPPIHPGEVLLEDFMKPLGLSQYRVAQDIGVPALRISQIVHGKRAVTADSAMRLARYFGTSPDVWLRLQARYDLE
VAEREYGERINREVKVLANAV

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References