Detailed information of TA system TA028576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2638474..2638736
• Replicon: chromosome
• Accession: NC_019770
• Organism: Enterococcus faecalis str. Symbioflor 1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EFS1_RS14550
• Protein ID: WP_002367458.1
• Coordinates: 2638593..2638736 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2638474..2638660 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFS1_RS13250	2633931..2636675	+	2745	WP_002411259.1	glycoside hydrolase family 65 protein	-
EFS1_RS13255	2636690..2637340	+	651	WP_002389419.1	beta-phosphoglucomutase	-
EFS1_RS13260	2637760..2638353	+	594	WP_002389391.1	hypothetical protein	-
-	2638474..2638660	+	187	-	-	Antitoxin
EFS1_RS14550	2638593..2638736	-	144	WP_002367458.1	putative holin-like toxin	Toxin
EFS1_RS13265	2638968..2639939	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
EFS1_RS13270	2640114..2640551	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
EFS1_RS13275	2640684..2641238	-	555	WP_002389433.1	septum formation protein Maf	-
EFS1_RS13280	2641263..2643395	-	2133	WP_002389406.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T28576 WP_002367458.1 NC_019770:c2638736-2638593 [Enterococcus faecalis str. Symbioflor 1]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T28576 NC_019770:c2638736-2638593 [Enterococcus faecalis str. Symbioflor 1]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT28576 NC_019770:2638474-2638660 [Enterococcus faecalis str. Symbioflor 1]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin