Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1740113..1740706 Replicon chromosome
Accession NZ_LN885086
Organism Candidatus Nitrospira inopinata isolate ENR4

Toxin (Protein)


Gene name higB Uniprot ID A0A0S4KUC7
Locus tag NITINOP_RS08365 Protein ID WP_062484746.1
Coordinates 1740113..1740403 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S4KTZ4
Locus tag NITINOP_RS08370 Protein ID WP_062487892.1
Coordinates 1740440..1740706 (+) Length 89 a.a.

Genomic Context

NITINOP_RS08350NITINOP_RS08355NITINOP_RS08360NITINOP_RS08365NITINOP_RS08370NITINOP_RS16140NITINOP_RS08390NITINOP_RS08395NITINOP_RS08345NITINOP_RS08375NITINOP_RS08380
Location: 1736250..1738733 (2484 bp)
Type: Others
Protein ID: WP_158023303.1
Location: 1738795..1739118 (324 bp)
Type: Others
Protein ID: WP_062484744.1
Location: 1739115..1740104 (990 bp)
Type: Others
Protein ID: WP_062484745.1
Location: 1740113..1740403 (291 bp)
Type: Toxin
Protein ID: WP_062484746.1
Location: 1740440..1740706 (267 bp)
Type: Antitoxin
Protein ID: WP_062487892.1
Location: 1740728..1740883 (156 bp)
Type: Others
Protein ID: WP_158023494.1
Location: 1743598..1744065 (468 bp)
Type: Others
Protein ID: WP_062484750.1
Location: 1744394..1745410 (1017 bp)
Type: Others
Protein ID: WP_162264704.1
Location: 1735295..1736053 (759 bp)
Type: Others
Protein ID: WP_062484742.1
Location: 1741367..1742857 (1491 bp)
Type: Others
Protein ID: WP_062484747.1
Location: 1742921..1743298 (378 bp)
Type: Others
Protein ID: WP_158023304.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NITINOP_RS083451735295..1736053-759WP_062484742.1hypothetical protein-
NITINOP_RS083501736250..1738733+2484WP_158023303.1ATP-dependent DNA helicase RecG-
NITINOP_RS083551738795..1739118+324WP_062484744.1hypothetical protein-
NITINOP_RS083601739115..1740104+990WP_062484745.1Ppx/GppA family phosphatase-
NITINOP_RS083651740113..1740403+291WP_062484746.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NITINOP_RS083701740440..1740706+267WP_062487892.1HigA family addiction module antidote proteinAntitoxin
NITINOP_RS161401740728..1740883+156WP_158023494.1hypothetical protein-
NITINOP_RS083751741367..1742857-1491WP_062484747.1class I SAM-dependent methyltransferase-
NITINOP_RS083801742921..1743298-378WP_158023304.1hypothetical protein-
NITINOP_RS083901743598..1744065+468WP_062484750.1hypothetical protein-
NITINOP_RS083951744394..1745410+1017WP_162264704.1pentapeptide repeat-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11389.85 Da        Isoelectric Point: 6.7274

>T285755 WP_062484746.1 NZ_LN885086:1740113-1740403 [Candidatus Nitrospira inopinata]
VIESFANRLAEDLFDDRQSKAVLKFPSDLIRTARRKLLYLHDASEIGDLREPPGNRLEALKGEWKGFYSIRINDQWRVVF
RWHDGNAYEVQIIDYH

Download         Length: 291 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10061.02 Da        Isoelectric Point: 11.2862

>AT285755 WP_062487892.1 NZ_LN885086:1740440-1740706 [Candidatus Nitrospira inopinata]
MRLPKNPFHPGEMLLEEFLIPRKMTQAALAKKLGWTRARLNELIKGKRDITADSALDLARVLGTSAKLWMNLQATFDLDK
AMRKRKIA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0S4KUC7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0S4KTZ4

References