Detailed information of TA system TA028575

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2566339..2566591
• Replicon: chromosome
• Accession: NC_019770
• Organism: Enterococcus faecalis str. Symbioflor 1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EFS1_RS12930
• Protein ID: WP_002393909.1
• Coordinates: 2566463..2566591 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2566339..2566518 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFS1_RS12900	2561558..2562511	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
EFS1_RS12905	2562550..2563305	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
EFS1_RS12910	2563302..2564267	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
EFS1_RS12915	2564264..2565211	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
EFS1_RS12920	2565396..2565848	+	453	WP_002389410.1	YueI family protein	-
EFS1_RS12925	2566030..2566157	-	128	Protein_2453	putative holin-like toxin	-
-	2566339..2566518	+	180	-	-	Antitoxin
EFS1_RS12930	2566463..2566591	-	129	WP_002393909.1	hypothetical protein	Toxin
EFS1_RS12935	2566754..2569024	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
EFS1_RS12940	2569195..2569695	+	501	WP_002372831.1	cysteine hydrolase	-
EFS1_RS12945	2570094..2570990	+	897	WP_002389477.1	YitT family protein	-
EFS1_RS12950	2571041..2571439	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T28575 WP_002393909.1 NC_019770:c2566591-2566463 [Enterococcus faecalis str. Symbioflor 1]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T28575 NC_019770:c2566591-2566463 [Enterococcus faecalis str. Symbioflor 1]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT28575 NC_019770:2566339-2566518 [Enterococcus faecalis str. Symbioflor 1]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin