Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5254315..5254910 Replicon chromosome
Accession NZ_LN871187
Organism Pseudomonas aeruginosa strain PAO1_Orsay

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PAO1OR_RS29675 Protein ID WP_003113526.1
Coordinates 5254632..5254910 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PAO1OR_RS24205 Protein ID WP_003113527.1
Coordinates 5254315..5254620 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAO1OR_RS29645 5249428..5249718 - 291 WP_033992920.1 DUF5447 family protein -
PAO1OR_RS24200 5249930..5250202 - 273 WP_003115921.1 hypothetical protein -
PAO1OR_RS29660 5250732..5251829 + 1098 WP_169917322.1 protein phosphatase 2C domain-containing protein -
PAO1OR_RS29665 5251832..5252881 + 1050 WP_003113529.1 serine/threonine protein kinase -
PAO1OR_RS29670 5252878..5253951 + 1074 WP_003113528.1 serine/threonine protein kinase -
PAO1OR_RS24205 5254315..5254620 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
PAO1OR_RS29675 5254632..5254910 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAO1OR_RS24210 5255239..5257467 + 2229 WP_003113525.1 TonB-dependent receptor -
PAO1OR_RS24215 5257537..5258184 - 648 WP_003095021.1 carbonate dehydratase -
PAO1OR_RS24220 5258246..5259484 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T285741 WP_003113526.1 NZ_LN871187:c5254910-5254632 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT285741 WP_003113527.1 NZ_LN871187:c5254620-5254315 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References