Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5190413..5191008 Replicon chromosome
Accession NZ_LN870292
Organism Pseudomonas aeruginosa DK1 substr. NH57388A

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PADK1_RS24560 Protein ID WP_003117425.1
Coordinates 5190730..5191008 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PADK1_RS24555 Protein ID WP_003113527.1
Coordinates 5190413..5190718 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PADK1_RS24520 5185553..5186401 + 849 WP_023103532.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PADK1_RS24530 5186568..5187509 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PADK1_RS24535 5187626..5188240 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PADK1_RS24540 5188282..5188866 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PADK1_RS24545 5188907..5190007 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PADK1_RS24555 5190413..5190718 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
PADK1_RS24560 5190730..5191008 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PADK1_RS24570 5191337..5193565 + 2229 WP_003113525.1 TonB-dependent receptor -
PADK1_RS24575 5193635..5194282 - 648 WP_003095021.1 carbonate dehydratase -
PADK1_RS24580 5194344..5195582 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T285734 WP_003117425.1 NZ_LN870292:c5191008-5190730 [Pseudomonas aeruginosa DK1]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT285734 WP_003113527.1 NZ_LN870292:c5190718-5190413 [Pseudomonas aeruginosa DK1]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References