Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 42016..42618 Replicon plasmid 3
Accession NZ_LN868945
Organism Salmonella enterica subsp. enterica serovar Senftenberg strain NCTC10384

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag AT698_RS21685 Protein ID WP_001159628.1
Coordinates 42016..42327 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AT698_RS21690 Protein ID WP_000362050.1
Coordinates 42328..42618 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT698_RS21650 37129..37728 + 600 WP_000965695.1 glucose-1-phosphatase -
AT698_RS21655 37722..38594 + 873 WP_000921423.1 virulence factor BrkB family protein -
AT698_RS21660 38591..39028 + 438 WP_000560969.1 D-tyrosyl-tRNA(Tyr) deacylase -
AT698_RS21665 39073..40014 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
AT698_RS21670 40029..40475 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
AT698_RS21675 40472..40783 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
AT698_RS21680 40869..41798 - 930 WP_001127701.1 alpha/beta hydrolase -
AT698_RS21685 42016..42327 + 312 WP_001159628.1 hypothetical protein Toxin
AT698_RS21690 42328..42618 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
AT698_RS21695 42665..43594 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
AT698_RS21700 43591..44226 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
AT698_RS21705 44223..45125 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..147787 147787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T285729 WP_001159628.1 NZ_LN868945:42016-42327 [Salmonella enterica subsp. enterica serovar Senftenberg]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT285729 WP_000362050.1 NZ_LN868945:42328-42618 [Salmonella enterica subsp. enterica serovar Senftenberg]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References