Detailed information of TA system TA285704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2449178..2449695
• Replicon: chromosome
• Accession: NZ_LN854556
• Organism: Staphylococcus aureus strain B155

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SABB155_RS12365
• Protein ID: WP_054189942.1
• Coordinates: 2449178..2449444 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SABB155_RS12370
• Protein ID: WP_054189941.1
• Coordinates: 2449444..2449695 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABB155_RS12345	2445388..2446212	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
SABB155_RS12350	2446415..2446597	-	183	WP_054189945.1	hypothetical protein	-
SABB155_RS12355	2446684..2447151	-	468	WP_054189944.1	SRPBCC domain-containing protein	-
SABB155_RS12360	2447337..2448884	-	1548	WP_054189943.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
SABB155_RS12365	2449178..2449444	-	267	WP_054189942.1	Txe/YoeB family addiction module toxin	Toxin
SABB155_RS12370	2449444..2449695	-	252	WP_054189941.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SABB155_RS12375	2449860..2449961	-	102	Protein_2349	hypothetical protein	-
SABB155_RS12380	2449968..2450567	-	600	WP_054189940.1	DsbA family protein	-
SABB155_RS12385	2450586..2450948	-	363	WP_054189939.1	DUF4467 domain-containing protein	-
SABB155_RS12390	2451204..2452454	+	1251	WP_054189938.1	FemA/FemB family glycyltransferase FmhA	-
SABB155_RS12395	2452549..2453280	-	732	WP_054189937.1	amino acid ABC transporter ATP-binding protein	-
SABB155_RS12400	2453277..2453996	-	720	WP_054189936.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2443618..2444934	1316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.94 Da
• Isoelectric Point: 10.0573

>T285704 WP_054189942.1 NZ_LN854556:c2449444-2449178 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.69 Da
• Isoelectric Point: 4.3407

>AT285704 WP_054189941.1 NZ_LN854556:c2449695-2449444 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Nucleotide

• Length: 252 bp