Detailed information of TA system TA285697

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1523223..1523802
• Replicon: chromosome
• Accession: NZ_LN854556
• Organism: Staphylococcus aureus strain B155

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SABB155_RS07395
• Protein ID: WP_001025401.1
• Coordinates: 1523557..1523802 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1523223..1523588 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABB155_RS07355	1519966..1520523	-	558	WP_000645042.1	DUF2815 family protein	-
SABB155_RS07360	1520549..1521715	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SABB155_RS07365	1521712..1522074	-	363	WP_000985984.1	hypothetical protein	-
SABB155_RS07370	1522089..1522412	-	324	WP_000175001.1	hypothetical protein	-
SABB155_RS07375	1522491..1522652	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SABB155_RS07380	1522665..1522928	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SABB155_RS07385	1522953..1523168	-	216	WP_001097552.1	hypothetical protein	-
SABB155_RS07390	1523223..1523588	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SABB155_RS07395	1523557..1523802	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SABB155_RS07400	1523858..1524067	+	210	WP_000642492.1	hypothetical protein	-
SABB155_RS07405	1524057..1524200	-	144	WP_000939498.1	hypothetical protein	-
SABB155_RS07410	1524229..1525005	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SABB155_RS07415	1525019..1525255	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SABB155_RS07420	1525407..1525721	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SABB155_RS07425	1525734..1526195	+	462	WP_000525004.1	hypothetical protein	-
SABB155_RS07430	1526213..1526647	+	435	WP_000755718.1	hypothetical protein	-
SABB155_RS07435	1526676..1527071	+	396	WP_000449655.1	hypothetical protein	-
SABB155_RS07440	1527161..1527307	+	147	WP_001795334.1	hypothetical protein	-
SABB155_RS07445	1527304..1527918	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1482606..1542007	59401

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T285697 WP_001025401.1 NZ_LN854556:c1523802-1523557 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT285697 NZ_LN854556:1523223-1523588 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin