Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1863019..1863674 Replicon chromosome
Accession NZ_LN849008
Organism Bordetella pertussis strain D420

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag BPD420_RS08945 Protein ID WP_047122780.1
Coordinates 1863019..1863270 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag BPD420_RS08950 Protein ID WP_003809516.1
Coordinates 1863273..1863674 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPD420_RS08920 1858180..1859310 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
BPD420_RS08925 1859545..1860126 + 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
BPD420_RS08930 1860263..1861327 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
BPD420_RS08935 1861412..1861858 - 447 WP_003819827.1 GFA family protein -
BPD420_RS08940 1862083..1862964 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
BPD420_RS08945 1863019..1863270 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
BPD420_RS08950 1863273..1863674 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BPD420_RS19885 1863694..1863930 + 237 WP_010930404.1 membrane protein -
BPD420_RS08955 1863938..1864417 + 480 WP_010930405.1 disulfide bond formation protein B -
BPD420_RS08960 1864567..1865082 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BPD420_RS08965 1865085..1866275 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BPD420_RS08970 1866295..1867332 + 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
BPD420_RS08975 1867469..1868491 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T285688 WP_047122780.1 NZ_LN849008:1863019-1863270 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT285688 WP_003809516.1 NZ_LN849008:1863273-1863674 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References