285682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 979535..980355 Replicon chromosome
Accession NZ_LN847264
Organism Pseudomonas sp. CCOS 191

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0F7Y1C6
Locus tag CCOS191_RS04520 Protein ID WP_046854219.1
Coordinates 979535..980032 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0F7XX37
Locus tag CCOS191_RS04525 Protein ID WP_046854220.1
Coordinates 980029..980355 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCOS191_RS04500 974714..976240 + 1527 WP_046854216.1 efflux transporter outer membrane subunit -
CCOS191_RS04505 976237..978414 + 2178 WP_046854217.1 FUSC family protein -
CCOS191_RS04510 978419..978619 + 201 WP_008097766.1 DUF1656 domain-containing protein -
CCOS191_RS04515 978630..979490 + 861 WP_046854218.1 HlyD family secretion protein -
CCOS191_RS04520 979535..980032 - 498 WP_046854219.1 type II toxin-antitoxin system YhaV family toxin Toxin
CCOS191_RS04525 980029..980355 - 327 WP_046854220.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
CCOS191_RS04530 980464..980910 - 447 WP_046854221.1 universal stress protein -
CCOS191_RS04535 981171..982076 + 906 WP_046854222.1 LysR family transcriptional regulator -
CCOS191_RS04540 982355..983896 + 1542 WP_046854223.1 MFS transporter -
CCOS191_RS04545 983924..984985 + 1062 WP_046854224.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 19122.90 Da        Isoelectric Point: 10.4165

>T285682 WP_046854219.1 NZ_LN847264:c980032-979535 [Pseudomonas sp. CCOS 191]
MTETRRKPLCVHGWSVFAHPLFLDKLEALIDEVEVLQRKDPVGYVKKNAAKRLKAIRRLAFDVIAQAPGNPDHRMGGTLG
AEHKHWFRAKFFQQYRLFFRYHASSKIIVLAWVNDDNSKRAYESSDDAYRVFRRMLGNGHPPDDWDQLLQEAAAATARFN
ATLKR

Download         Length: 498 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12069.53 Da        Isoelectric Point: 4.2140

>AT285682 WP_046854220.1 NZ_LN847264:c980355-980029 [Pseudomonas sp. CCOS 191]
MATTFEAESTLTERYQTTVPETVRRALGLKKRDKIHYSIRPDGAVILTRAETAEEDPAVGQFLEFLERDIATNPQRLKVV
DAELVARLDALVGDVEIDLDQPLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7Y1C6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7XX37

References