Detailed information of TA system TA285680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 30507..31062
• Replicon: chromosome
• Accession: NZ_LN847264
• Organism: Pseudomonas sp. CCOS 191

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CCOS191_RS26915
• Protein ID: WP_172670864.1
• Coordinates: 30805..31062 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0F7XUM4
• Locus tag: CCOS191_RS00140
• Protein ID: WP_046853585.1
• Coordinates: 30507..30791 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCOS191_RS00115	26061..26993	-	933	WP_046853582.1	methionyl-tRNA formyltransferase	-
CCOS191_RS00120	27056..27562	-	507	WP_038707094.1	peptide deformylase	-
CCOS191_RS00125	27772..28869	+	1098	WP_046853583.1	DNA-processing protein DprA	-
CCOS191_RS00130	28908..29465	+	558	WP_038707096.1	L-threonylcarbamoyladenylate synthase	-
CCOS191_RS00135	29901..30212	+	312	WP_046853584.1	hypothetical protein	-
CCOS191_RS00140	30507..30791	+	285	WP_046853585.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CCOS191_RS26915	30805..31062	+	258	WP_172670864.1	Txe/YoeB family addiction module toxin	Toxin
CCOS191_RS00145	31147..32124	-	978	WP_046853586.1	NADPH:quinone reductase	-
CCOS191_RS00150	32257..33168	+	912	WP_046853587.1	oxygen-dependent coproporphyrinogen oxidase	-
CCOS191_RS00155	33194..34018	+	825	WP_046853588.1	shikimate dehydrogenase	-
CCOS191_RS00160	34193..35758	-	1566	WP_046853589.1	SulP family inorganic anion transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9961.19 Da
• Isoelectric Point: 6.8599

>T285680 WP_172670864.1 NZ_LN847264:30805-31062 [Pseudomonas sp. CCOS 191]
VSVAFTAEGWDDYHHWREADSAIFETINVLIRESCRTPFKGTGKPEPLKGDLSGFWSRRITREHRLVYLYEGGQLTVLQC
RFHYD

Nucleotide

• Length: 258 bp

>T285680 NZ_LN847264:30805-31062 [Pseudomonas sp. CCOS 191]
GTGAGCGTTGCGTTCACTGCCGAGGGATGGGACGACTATCACCATTGGCGGGAAGCTGATTCGGCGATCTTCGAGACAAT
CAATGTGCTGATCCGCGAGTCCTGCCGTACGCCTTTCAAAGGAACGGGCAAACCTGAACCCCTAAAGGGTGATCTTTCCG
GATTCTGGTCTCGCCGCATCACCCGAGAGCATCGTCTGGTCTACCTGTATGAGGGCGGCCAGTTGACGGTGCTGCAGTGC
CGGTTTCATTACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10697.02 Da
• Isoelectric Point: 4.8258

>AT285680 WP_046853585.1 NZ_LN847264:30507-30791 [Pseudomonas sp. CCOS 191]
MHVLTFSQARADLKQTMDDVCRDHEPAIITRQRGEPVVMLSLEDYNGMQETLYLLGSSANARRLRSSVEQLRSGQPVTQE
LIIDEHEVKATQQD

Nucleotide

• Length: 285 bp

>AT285680 NZ_LN847264:30507-30791 [Pseudomonas sp. CCOS 191]
ATGCATGTACTGACTTTTAGCCAAGCTCGCGCCGACCTGAAGCAAACGATGGATGACGTATGCCGTGACCACGAGCCGGC
GATCATCACGCGCCAACGTGGCGAGCCGGTGGTCATGCTGTCCCTGGAGGATTACAACGGCATGCAGGAGACCCTTTACT
TGCTAGGGTCATCTGCCAACGCAAGGCGCTTGCGTTCATCAGTCGAGCAGCTGCGGTCGGGTCAGCCAGTTACTCAAGAG
CTGATCATCGATGAACATGAAGTCAAAGCAACGCAACAAGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0F7XUM4