285663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2092147..2092649 Replicon chromosome
Accession NZ_LN832404
Organism Escherichia coli K-12 substr. AG100

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EK12AG100_RS10595 Protein ID WP_000767829.1
Coordinates 2092147..2092401 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EK12AG100_RS10600 Protein ID WP_001259255.1
Coordinates 2092398..2092649 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK12AG100_RS10570 2087162..2087389 - 228 WP_000234896.1 sulfurtransferase TusA -
EK12AG100_RS10575 2087403..2088461 - 1059 WP_000492339.1 transport protein YeeE -
EK12AG100_RS10580 2088640..2089998 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EK12AG100_RS25690 2089988..2090050 - 63 WP_010723108.1 membrane protein YoeI -
EK12AG100_RS10585 2090265..2091194 - 930 WP_000803351.1 LysR family transcriptional regulator -
EK12AG100_RS10590 2091240..2092064 - 825 WP_000754737.1 SDR family oxidoreductase -
EK12AG100_RS10595 2092147..2092401 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EK12AG100_RS10600 2092398..2092649 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EK12AG100_RS24025 2092932..2092982 + 51 WP_001364200.1 his operon leader peptide -
EK12AG100_RS10605 2093128..2094027 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EK12AG100_RS10610 2094033..2095337 + 1305 WP_000009594.1 histidinol dehydrogenase -
EK12AG100_RS10615 2095334..2096404 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
EK12AG100_RS10620 2096404..2097471 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T285663 WP_000767829.1 NZ_LN832404:c2092401-2092147 [Escherichia coli K-12]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT285663 WP_001259255.1 NZ_LN832404:c2092649-2092398 [Escherichia coli K-12]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References