Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5598280..5598794 Replicon chromosome
Accession NZ_LN831790
Organism Streptomyces leeuwenhoekii strain

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0F7VWP6
Locus tag BN2145_RS25425 Protein ID WP_029385725.1
Coordinates 5598280..5598534 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F7W559
Locus tag BN2145_RS25430 Protein ID WP_029385726.1
Coordinates 5598531..5598794 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2145_RS25395 5593578..5595032 - 1455 WP_029385722.1 sugar kinase -
BN2145_RS25400 5595135..5595437 - 303 WP_029385723.1 YtxH domain-containing protein -
BN2145_RS25420 5596814..5598286 + 1473 WP_049976854.1 NACHT domain-containing protein -
BN2145_RS25425 5598280..5598534 - 255 WP_029385725.1 Txe/YoeB family addiction module toxin Toxin
BN2145_RS25430 5598531..5598794 - 264 WP_029385726.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BN2145_RS25435 5599018..5599896 - 879 WP_047122048.1 class I SAM-dependent methyltransferase -
BN2145_RS36965 5600065..5600223 - 159 WP_164497191.1 hypothetical protein -
BN2145_RS25440 5600220..5601092 - 873 WP_063833346.1 cytochrome c oxidase assembly protein -
BN2145_RS25445 5601148..5601618 - 471 WP_047122049.1 DUF2243 domain-containing protein -
BN2145_RS25450 5601615..5602184 - 570 WP_029385730.1 hemerythrin domain-containing protein -
BN2145_RS25455 5602186..5603388 - 1203 WP_029385731.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10033.38 Da        Isoelectric Point: 9.2906

>T285647 WP_029385725.1 NZ_LN831790:c5598534-5598280 [Streptomyces leeuwenhoekii]
VRISFTSHAWGDYTYWAESDRKMVKRINKLIDDTMRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDELIIVQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9803.88 Da        Isoelectric Point: 4.6830

>AT285647 WP_029385726.1 NZ_LN831790:c5598794-5598531 [Streptomyces leeuwenhoekii]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFNSWTETVHLLRSPKNARRLLDSIAEAEAGEVQHRELI
DPDAERA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7VWP6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7W559

References