Detailed information of TA system TA285625

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2026362..2026661
• Replicon: chromosome
• Accession: NZ_LN831036
• Organism: Staphylococcus aureus strain NCTC13435

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: AT694_RS14680
• Protein ID: WP_072353918.1
• Coordinates: 2026485..2026661 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2026362..2026417 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT694_RS10145	2021920..2022099	+	180	WP_000669791.1	hypothetical protein	-
AT694_RS10155	2022410..2022670	+	261	WP_001791826.1	hypothetical protein	-
AT694_RS10160	2022723..2023073	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AT694_RS10165	2023584..2023919	-	336	Protein_1913	SH3 domain-containing protein	-
AT694_RS10170	2024570..2025061	-	492	WP_000920038.1	staphylokinase	-
AT694_RS10175	2025252..2026007	-	756	WP_000861038.1	CHAP domain-containing protein	-
AT694_RS10180	2026019..2026273	-	255	WP_000611512.1	phage holin	-
AT694_RS10185	2026325..2026432	+	108	WP_001791821.1	hypothetical protein	-
-	2026354..2026493	+	140	NuclAT_0	-	-
-	2026354..2026493	+	140	NuclAT_0	-	-
-	2026354..2026493	+	140	NuclAT_0	-	-
-	2026354..2026493	+	140	NuclAT_0	-	-
-	2026362..2026417	+	56	-	-	Antitoxin
AT694_RS14680	2026485..2026661	-	177	WP_072353918.1	putative holin-like toxin	Toxin
AT694_RS10190	2026804..2027178	-	375	WP_000340977.1	hypothetical protein	-
AT694_RS10195	2027234..2027521	-	288	WP_001262620.1	hypothetical protein	-
AT694_RS10200	2027567..2027719	-	153	WP_001000058.1	hypothetical protein	-
AT694_RS10205	2027712..2031494	-	3783	Protein_1922	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2022723..2074416	51693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T285625 WP_072353918.1 NZ_LN831036:c2026661-2026485 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT285625 NZ_LN831036:2026362-2026417 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin